A purine nucleoside analogue-acyclovir [9-(2-hydroxyethoxymethyl)-9h-guanine] reversibly impairs testicular functions in mouse

P-51: A Purine Nucleoside Analogue_Acyclovir Impairs Testicular Functions in Male Rats

Background: Acyclovir (ACV) is a synthetic purine nucleoside analog drived from guanosine. ACV possesses antiviral activity against Herpes Simplex Virus types 1 and 2 (HSV-1 and HSV-2 ), Varicella Zoster virus (VZV) , Epstein Barr virus (EBV) and Cytomegalovirus (CMV). ACV exert its effects by interfering with DNA synthesis,thus inhibiting viral replication. ACV is khown to be toxic to gonads,t...

Effect of Purine Nucleoside Analogue-Acyclovir on The Sperm Parameters and Testosterone Production in Rats

6-Chloro-9-(2-nitro­phenyl­sulfon­yl)-9H-purine

The title compound, C(11)H(6)ClN(5)O(4)S, crystallized with two independent mol-ecules in the asymmetric unit. The benzene ring makes dihedral angles of 66.46 (8) and 85.77 (9)° with the mean plane of the purine ring in the two mol-ecules. In the crystal, inter-molecular π-π stacking inter-actions [centroid-centroid distance = 3.8968 (12) Å], C-Cl⋯π inter-actions [Cl⋯centroid = 3.2505 (10) Å, C...

effect of purine nucleoside analogue-acyclovir on the sperm parameters and testosterone production in rats

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Effect of Purine Nucleoside Analogue-Acyclovir on The Sperm Parameters and Testosterone Production in Rats

BACKGROUND Acyclovir (ACV), a synthetic purine nucleoside analogue derived from guanosine, is known to be toxic to gonads and the aim of this study was to evaluate the effect of ACV on the sperm parameters and testosterone production in rat. MATERIALS AND METHODS In this experimental study, forty adult male Wistar rats (220 ± 20 g) were randomly divided into five groups (n=8 for each group). ...